Dupuytren's Contracture
Dupuytren's contracture is a progressive condition of the palm in which the connective tissue beneath the skin thickens and tightens, eventually forming cords that pull the fingers into a bent position. Many patients first notice a painless nodule in the palm near the ring or small finger. Over months to years, that nodule may develop into a firm cord stretching into the finger, gradually preventing full extension. At Maryland Orthopedic Specialists, our hand surgeons offer all three major treatment options — needle aponeurotomy, collagenase injection, and surgical fasciectomy — and help each patient choose the approach best suited to their anatomy, severity, and lifestyle.
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What is dupuytren's contracture?
Dupuytren's contracture arises from pathological transformation of the normal palmar fascia — the sheet of fibrous tissue that lies just beneath the palm skin — into thickened, collagen-rich nodules and cords. These structures contract over time, tethering the overlying skin and eventually causing fixed-flexion contracture at the metacarpophalangeal (MCP) and/or proximal interphalangeal (PIP) joints of the affected fingers.
Dupuytren's contracture arises from pathological transformation of the normal palmar fascia — the sheet of fibrous tissue that lies just beneath the palm skin — into thickened, collagen-rich nodules and cords. These structures contract over time, tethering the overlying skin and eventually causing fixed-flexion contracture at the metacarpophalangeal (MCP) and/or proximal interphalangeal (PIP) joints of the affected fingers.
The ring finger is most commonly affected, followed by the small, middle, and index fingers. The thumb is rarely involved. Bilateral disease is present in approximately 45% of patients at diagnosis.
Dupuytren's Diathesis
Dupuytren's diathesis refers to a constellation of features associated with a more aggressive disease course and higher recurrence after treatment: bilateral hand disease, plantar fibromatosis (Ledderhose disease), penile fibromatosis (Peyronie's disease), knuckle pads (Garrod's pads), young age at onset (before 50), and a strong family history. Patients with high diathesis scores may choose more definitive surgical treatment over needle or injection-based options due to higher expected recurrence rates.
Risk Factors
- Northern European (Scandinavian, British, Irish, Dutch) ancestry
- Male sex (7:1 male-to-female ratio)
- Age over 50
- Family history
- Diabetes mellitus (associated with atypical "diabetic cheiroarthropathy")
- Alcohol use, smoking, and manual labor (less strongly supported by evidence)
Treatment options
Needle Aponeurotomy
This is the least invasive option, done right in the office using a needle to break up the cord through small skin punctures. Recovery is quick — most patients are back to light activity within a day or two. It works well for straightening fingers bent at the knuckle, but the cord is more likely to return over time compared to surgery.
Collagenase Injection (Xiaflex)
An enzyme is injected into the cord during an office visit, which weakens the cord's structure. The patient returns the next day so the doctor can gently straighten the finger and complete the release. This is a good option for a single cord affecting the knuckle joint, and the whole process takes just two office visits.
Frequently Asked Questions
Is Dupuytren's painful?
Will it keep getting worse without treatment?
Which treatment is best?
Can Dupuytren's come back after surgery?
How long does recovery take after needle aponeurotomy or surgery for Dupuytren's contracture?
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References
- Huisstede BM, Hoogvliet P, Paulis WD, et al. Effectiveness of interventions for treating Dupuytren disease: an updated systematic review. Archives of Physical Medicine and Rehabilitation. 2022;103(1):121–140. doi:10.1016/j.apmr.2021.06.012
- Nydick JA, Olliff BW, Garcia MJ, Hess AV, Stone JD. A comparison of percutaneous needle fasciotomy and collagenase injection for Dupuytren disease. Journal of Hand Surgery (American Volume). 2013;38(12):2377–2381. doi:10.1016/j.jhsa.2013.08.096
- Dias JJ, Braybrooke J. Dupuytren's disease: an audit of the outcomes of surgery. Journal of Hand Surgery (British Volume). 2006;31(5):514–521. doi:10.1016/j.jhsb.2006.03.180
- Hovius SE, Kan HJ, Smit X, et al. Extensive percutaneous aponeurotomy and lipofilling: a new treatment for Dupuytren disease. Plastic and Reconstructive Surgery. 2011;128(1):221–228. doi:10.1097/PRS.0b013e31821741ba
- van Rijssen AL, ter Linden H, Werker PM. Five-year results of a randomized clinical trial on treatment in Dupuytren's disease: percutaneous needle fasciotomy versus limited fasciectomy. Plastic and Reconstructive Surgery. 2012;129(2):469–477. doi:10.1097/PRS.0b013e31823aea95
