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Maryland Orthopedic Specialists
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Piriformis Syndrome (Deep Gluteal Syndrome)

Piriformis syndrome — more broadly classified as deep gluteal syndrome — occurs when the sciatic nerve is compressed or irritated in the deep gluteal space, causing buttock pain and posterior leg symptoms. Often misdiagnosed as lumbar disc herniation, it is an important and treatable diagnosis when lumbar pathology has been excluded. At Maryland Orthopedic Specialists, our sports medicine team provides a systematic approach to buttock and leg pain, from targeted injections to endoscopic sciatic nerve decompression when necessary.

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What is piriformis syndrome (deep gluteal syndrome)?

The piriformis muscle originates from the anterior sacrum and inserts on the greater trochanter, serving as a primary external rotator of the hip. The sciatic nerve — the body's largest peripheral nerve — exits the pelvis through the greater sciatic foramen, passing directly beneath (or in anatomic variants, through) the piriformis muscle.

The piriformis muscle originates from the anterior sacrum and inserts on the greater trochanter, serving as a primary external rotator of the hip. The sciatic nerve — the body's largest peripheral nerve — exits the pelvis through the greater sciatic foramen, passing directly beneath (or in anatomic variants, through) the piriformis muscle.

Deep gluteal syndrome is the modern term encompassing all causes of sciatic nerve compression in the deep gluteal space, including:

  • Piriformis syndrome: Piriformis muscle hypertrophy, spasm, or fibrosis compressing the sciatic nerve
  • Fibrovascular bands tethering the sciatic nerve
  • Hamstring origin pathology (proximal hamstring tendinopathy causing nerve adhesion)
  • Obturator internus pathology

Piriformis syndrome accounts for approximately 6–8% of all cases of sciatica and is significantly underdiagnosed, particularly when lumbar imaging is unremarkable or normal.

Frequently Asked Questions

How do I know if my sciatica is from my back or my piriformis?
Back-generated sciatica typically changes with lumbar movements (bending forward or backward) and is associated with low back pain. Piriformis syndrome is worse with sitting and hip external rotation but does not vary with lumbar loading. A normal lumbar MRI and positive FAIR test support a deep gluteal source.
Is piriformis syndrome a permanent condition?
Most patients respond well to PT and injection. Even refractory cases can achieve significant relief with endoscopic decompression. Long-term prognosis is generally good with appropriate treatment.
Can I exercise with piriformis syndrome?
Low-impact activities that do not require prolonged hip flexion or sitting — cycling, swimming, walking — are generally tolerated. Avoid extended running or any activity that reproduces the buttock/leg pain until symptoms are controlled.
What treatments are available for piriformis syndrome, and do they work?
The first line of treatment is physical therapy targeting piriformis stretching, hip external rotator strengthening, and biomechanical correction, which resolves symptoms in the majority of patients when followed consistently. Anti-inflammatory medications can help manage acute pain. For patients who do not improve with therapy, ultrasound- or fluoroscopy-guided injections of corticosteroid or botulinum toxin directly into the piriformis muscle can provide significant, lasting relief. Surgical release of the piriformis muscle is reserved for a small subset of patients with refractory symptoms, and at MOS our surgeons are experienced in both endoscopic and open techniques for deep gluteal decompression.
How long does it take to recover from piriformis syndrome?
Recovery time varies considerably based on how long symptoms have been present and how faithfully rehabilitation is pursued. Many patients with early or mild symptoms notice improvement within 4–6 weeks of consistent physical therapy. Those with longer-standing compression or more severe nerve irritation may require 3–6 months of treatment before symptoms fully resolve. It is important to address underlying contributing factors — such as hip labral pathology, leg-length discrepancy, or training errors — to prevent recurrence, and your MOS care team will evaluate for these during your workup.

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John J. Christoforetti, MD

John J. Christoforetti, MD

Orthopedic Surgery · Sports Medicine · Hip Preservation Surgery

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Medically reviewed by John J. Christoforetti, MD, MD, FAAOS
Last reviewed May 1, 2026

References

  1. Boyajian-O'Neill LA, McClain RL, Coleman MK, Thomas PP. Diagnosis and management of piriformis syndrome: an osteopathic approach. J Am Osteopath Assoc. 2008;108(11):657–664. https://doi.org/10.7556/jaoa.2008.108.11.657
  2. Martin HD, Shears SA, Johnson JC, Smathers AM, Palmer IJ. The endoscopic treatment of sciatic nerve entrapment/deep gluteal syndrome. Arthroscopy. 2011;27(2):172–181. https://doi.org/10.1016/j.arthro.2010.07.008
  3. Fishman LM, Dombi GW, Michaelsen C, et al. Piriformis syndrome: diagnosis, treatment, and outcome — a 10-year study. Arch Phys Med Rehabil. 2002;83(3):295–301. https://doi.org/10.1053/apmr.2002.28bromide
  4. Michel F, Décavel P, Toussirot E, et al. Piriformis muscle syndrome: diagnostic criteria and treatment of a monocentric series of 250 patients. Ann Phys Rehabil Med. 2013;56(5):371–383. https://doi.org/10.1016/j.rehab.2013.04.003
  5. American Academy of Orthopaedic Surgeons. Hip Anatomy. OrthoInfo. https://orthoinfo.aaos.org/en/diseases--conditions/hip-anatomy/